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Feb. 8, 2013 ? Findings from clinical trial patients with metastatic renal cell carcinoma, a common kidney cancer, show they did not have accelerated tumor growth after treatment with sunitinib, in contrast to some study results in animals. Sunitinib is one of several drugs, either on the market or undergoing testing, that target blood vessel growth. There had been debate, based on the animal studies, about whether tumor blood vessel changes induced by these drugs promoted tumor growth and/or caused cancer to spread. In this study, Tito Fojo, M.D., Ph.D., head of the Experimental Therapeutics Section, Medical Oncology Branch and Affiliates, NCI, and his colleagues, found that not to be the case.
Results of their study appeared in Cell Reports, Feb. 7, 2013.
Using a mouse model to assess small, relatively newly developed tumors can be much more challenging than assessment in humans who tend to have more established tumors several centimeters in size. To address whether sunitinib accelerated tumor growth in humans, researchers analyzed data from a randomized phase III trial comparing sunitinib with interferon alfa in patients with kidney cancer. Using a novel methodology for assessing efficacy , they found sunitinib reduced the tumor's growth rate while improving survival, without appearing to negatively alter tumor biology after discontinuation.
Their findings suggest that concerns arising from animal models may not apply to patients receiving sunitinib and most likely will not apply to patients using similar agents, but recognize more studies may need to be done.
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The above story is reprinted from materials provided by National Cancer Institute (NCI) at NIH.
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Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/n4HzwcTVDqk/130208124601.htm
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3 beds, 2 full baths
Home size: 1,423 sq ft
Year built: 1998
Walk Score?: 8
2 beds, 2 full baths
Home size: 872 sq ft
Lot size: 7,500 sqft
Year built: 2000
Walk Score?: 14
3 beds, 2 full baths
Home size: 1,320 sq ft
Lot size: 7,500 sqft
Year built: 2008
Walk Score?: 11
3 beds, 2 full baths
Home size: 1,616 sq ft
Lot size: 1.96 ac
Year built: 1996
Walk Score?: 12
2 beds, 2 full baths
Home size: 1,970 sq ft
Lot size: 5,580 sqft
Year built: 1980
Walk Score?: 38
4 beds, 2 full baths
Home size: 2,215 sq ft
Lot size: 6,968 sqft
Year built: 2005
Walk Score?: 20
3 beds, 2 full, 1 part baths
Home size: 1,717 sq ft
Lot size: 10,500 sqft
Year built: 1995
Walk Score?: 37
3 beds, 2 full baths
Home size: 1,538 sq ft
Year built: 1989
Parking spots: 1
Walk Score?: 49
3 beds, 2 full baths
Home size: 1,600 sq ft
Year built: 2006
3 beds, 2 full baths
Home size: 2,064 sq ft
Year built: 1979
Parking spots: 2
Walk Score?: 0
2 beds, 2 full baths
Home size: 1,296 sq ft
Lot size: 5,520 sqft
Year built: 1989
Walk Score?: 6
2 beds, 2 full baths
Home size: 1,135 sq ft
Lot size: 4,800 sqft
Year built: 1993
Walk Score?: 40
2 beds, 1 full bath
Home size: 1,423 sq ft
Year built: 1994
Walk Score?: 32
2 beds, 2 full, 1 part baths
Home size: 1,132 sq ft
Year built: 1985
Walk Score?: 60
3 beds, 2 full baths
Home size: 1,701 sq ft
Lot size: 5,400 sqft
Year built: 1990
Walk Score?: 23
3 beds, 3 full baths
Home size: 1,706 sq ft
Year built: 2000
Walk Score?: 37
3 beds, 2 full baths
Home size: 1,595 sq ft
Lot size: 5,070 sqft
Year built: 1988
Walk Score?: 18
3 beds, 1 full bath
Home size: 1,090 sq ft
Year built: 1960
Walk Score?: 57
3 beds, 2 full baths
Home size: 1,251 sq ft
Lot size: 1,222 sqft
Year built: 1984
4 beds, 4 full, 1 part baths
Home size: 3,383 sq ft
Year built: 2005
Parking spots: 4
Walk Score?: 26
5 beds, 4 full, 1 part baths
Home size: 2,400 sq ft
Year built: 2007
Walk Score?: 17
3 beds, 1 full bath
Home size: 1,423 sq ft
Lot size: 7,985 sqft
Year built: 1959
Walk Score?: 58
3 beds, 2 full baths
Home size: 1,568 sq ft
Year built: 1980
Parking spots: 1
Walk Score?: 35
5 beds, 4 full, 1 part baths
Home size: 3,713 sq ft
Lot size: 32,896 sqft
Year built: 2001
Parking spots: 4
Walk Score?: 2
4 beds, 2 full baths
Home size: 1,505 sq ft
Year built: 1980
Walk Score?: 6
4 beds, 3 full, 1 part baths
Home size: 3,204 sq ft
Year built: 2009
Walk Score?: 34
3 beds, 2 full baths
Home size: 1,108 sq ft
Year built: 1981
Walk Score?: 6
3 beds, 2 full baths
Home size: 1,350 sq ft
Lot size: 21,150 sqft
Year built: 1960
Parking spots: 4
Walk Score?: 23
4 beds, 2 full baths
Home size: 2,035 sq ft
Year built: 2003
4 beds, 2 full, 2 part baths
Home size: 3,100 sq ft
Lot size: 15,000 sqft
Year built: 2003
Walk Score?: 34
3 beds, 2 full baths
Home size: 1,509 sq ft
Lot size: 7,245 sqft
Year built: 2004
Walk Score?: 3
3 beds, 2 full baths
Home size: 2,144 sq ft
Year built: 1990
Walk Score?: 0
3 beds, 3 full baths
Home size: 2,420 sq ft
Year built: 2002
Parking spots: 4
Walk Score?: 45
3 beds, 2 full baths
Home size: 1,697 sq ft
Year built: 2009
4 beds, 4 full baths
Home size: 2,200 sq ft
Lot size: 24,948 sqft
Year built: 2005
Walk Score?: 15
3 beds, 2 full baths
Home size: 1,295 sq ft
Year built: 1977
Walk Score?: 22
2 beds, 1 full, 1 part baths
Home size: 900 sq ft
Year built: 1983
Walk Score?: 92
2 beds, 2 full baths
Home size: 1,202 sq ft
Year built: 2007
Walk Score?: 42
2 beds, 2 full baths
Home size: 1,202 sq ft
Year built: 2007
Walk Score?: 42
3 beds, 2 full baths
Home size: 1,463 sq ft
Year built: 2007
Walk Score?: 42
2 beds, 2 full baths
Home size: 1,202 sq ft
Year built: 2007
Walk Score?: 42
3 beds, 2 full baths
Home size: 1,463 sq ft
Year built: 2007
Walk Score?: 42
2 beds, 2 full baths
Home size: 1,202 sq ft
Year built: 2007
Walk Score?: 42
2 beds, 2 full baths
Home size: 1,202 sq ft
Year built: 2007
Walk Score?: 42
3 beds, 2 full baths
Home size: 1,463 sq ft
Year built: 2007
Walk Score?: 42
3 beds, 2 full baths
Home size: 1,463 sq ft
Year built: 2007
Walk Score?: 42
3 beds, 2 full baths
Home size: 1,463 sq ft
Year built: 2007
Walk Score?: 42
2 beds, 2 full baths
Home size: 1,202 sq ft
Year built: 2007
Walk Score?: 42
4 beds, 2 full baths
Home size: 2,500 sq ft
Lot size: 6,893 sqft
Year built: 1961
Walk Score?: 32
4 beds, 4 full baths
Home size: 2,231 sq ft
Year built: 2001
Walk Score?: 31
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Thinking about injecting an identification chip in your pooch? If you live in the southern part of the UK, you won't have a choice. Come 2016, English authorities will require all of the country's pups to have embedded microchips, so they can be returned to their owners if ever they run astray. The United Kingdom's Environment Department says some 60 percent of the country's 8 million dogs already have the tags, but beginning in three years, owners who don't spring for the device could be forced to pay fines of up to £500 (about $780). Cat microchipping will remain optional, since felines are less likely to wander outdoors. And "World's Cutest Dog" fans need not worry about their precious Boo getting the forced implant -- the famed Pomeranian (pictured above) is based in San Francisco, some 5,000 miles from the Queen's needle.
Filed under: Misc
Source: AP (Huffington Post)
Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/MkHGkauZHfQ/
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