Saturday 9 February 2013

The Secretary of the Treasury: from tax cheat to ?tax scam? beneficiary (Powerlineblog)

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Sunitinib benefits patients with renal cell carcinoma, study suggests

Feb. 8, 2013 ? Findings from clinical trial patients with metastatic renal cell carcinoma, a common kidney cancer, show they did not have accelerated tumor growth after treatment with sunitinib, in contrast to some study results in animals. Sunitinib is one of several drugs, either on the market or undergoing testing, that target blood vessel growth. There had been debate, based on the animal studies, about whether tumor blood vessel changes induced by these drugs promoted tumor growth and/or caused cancer to spread. In this study, Tito Fojo, M.D., Ph.D., head of the Experimental Therapeutics Section, Medical Oncology Branch and Affiliates, NCI, and his colleagues, found that not to be the case.

Results of their study appeared in Cell Reports, Feb. 7, 2013.

Using a mouse model to assess small, relatively newly developed tumors can be much more challenging than assessment in humans who tend to have more established tumors several centimeters in size. To address whether sunitinib accelerated tumor growth in humans, researchers analyzed data from a randomized phase III trial comparing sunitinib with interferon alfa in patients with kidney cancer. Using a novel methodology for assessing efficacy , they found sunitinib reduced the tumor's growth rate while improving survival, without appearing to negatively alter tumor biology after discontinuation.

Their findings suggest that concerns arising from animal models may not apply to patients receiving sunitinib and most likely will not apply to patients using similar agents, but recognize more studies may need to be done.

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The above story is reprinted from materials provided by National Cancer Institute (NCI) at NIH.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Krastan?B. Blagoev, Julia Wilkerson, Wilfred?D. Stein, Robert?J. Motzer, Susan?E. Bates, A.?Tito Fojo. Sunitinib Does Not Accelerate Tumor Growth in Patients with Metastatic Renal Cell Carcinoma. Cell Reports, 2013; DOI: 10.1016/j.celrep.2013.01.015

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/n4HzwcTVDqk/130208124601.htm

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Friday 8 February 2013

Flickr Is Back, Letting Us Go Home Again

Flickr Is Back, Letting Us Go Home Again
While it is too soon to say that Flickr is going to be bigger than Facebook or Instagram, there's a lot going on that indicates it's primed for a return.

Source: http://feedproxy.google.com/~r/GearFactor/~3/_RWUGwc6r_8/

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Today's Top Foreclosures | Hartley Real Estate Team

Showing properties 1 - 50 of 51. See more Foreclosures.
(all data current as of 2/7/2013)

  1. 3 beds, 2 full baths

    Home size: 1,423 sq ft

    Year built: 1998

    Walk Score?: 8

  2. 2 beds, 2 full baths

    Home size: 872 sq ft

    Lot size: 7,500 sqft

    Year built: 2000

    Walk Score?: 14

  3. 3 beds, 2 full baths

    Home size: 1,320 sq ft

    Lot size: 7,500 sqft

    Year built: 2008

    Walk Score?: 11

  4. 3 beds, 2 full baths

    Home size: 1,616 sq ft

    Lot size: 1.96 ac

    Year built: 1996

    Walk Score?: 12

  5. 2 beds, 2 full baths

    Home size: 1,970 sq ft

    Lot size: 5,580 sqft

    Year built: 1980

    Walk Score?: 38

  6. 4 beds, 2 full baths

    Home size: 2,215 sq ft

    Lot size: 6,968 sqft

    Year built: 2005

    Walk Score?: 20

  7. 3 beds, 2 full, 1 part baths

    Home size: 1,717 sq ft

    Lot size: 10,500 sqft

    Year built: 1995

    Walk Score?: 37

  8. 3 beds, 2 full baths

    Home size: 1,538 sq ft

    Year built: 1989

    Parking spots: 1

    Walk Score?: 49

  9. 3 beds, 2 full baths

    Home size: 1,600 sq ft

    Year built: 2006

  10. 3 beds, 2 full baths

    Home size: 2,064 sq ft

    Year built: 1979

    Parking spots: 2

    Walk Score?: 0

  11. 2 beds, 2 full baths

    Home size: 1,296 sq ft

    Lot size: 5,520 sqft

    Year built: 1989

    Walk Score?: 6

  12. 2 beds, 2 full baths

    Home size: 1,135 sq ft

    Lot size: 4,800 sqft

    Year built: 1993

    Walk Score?: 40

  13. 2 beds, 1 full bath

    Home size: 1,423 sq ft

    Year built: 1994

    Walk Score?: 32

  14. 2 beds, 2 full, 1 part baths

    Home size: 1,132 sq ft

    Year built: 1985

    Walk Score?: 60

  15. 3 beds, 2 full baths

    Home size: 1,701 sq ft

    Lot size: 5,400 sqft

    Year built: 1990

    Walk Score?: 23

  16. 3 beds, 3 full baths

    Home size: 1,706 sq ft

    Year built: 2000

    Walk Score?: 37

  17. 3 beds, 2 full baths

    Home size: 1,595 sq ft

    Lot size: 5,070 sqft

    Year built: 1988

    Walk Score?: 18

  18. 3 beds, 1 full bath

    Home size: 1,090 sq ft

    Year built: 1960

    Walk Score?: 57

  19. 3 beds, 2 full baths

    Home size: 1,251 sq ft

    Lot size: 1,222 sqft

    Year built: 1984

  20. 4 beds, 4 full, 1 part baths

    Home size: 3,383 sq ft

    Year built: 2005

    Parking spots: 4

    Walk Score?: 26

  21. 5 beds, 4 full, 1 part baths

    Home size: 2,400 sq ft

    Year built: 2007

    Walk Score?: 17

  22. 3 beds, 1 full bath

    Home size: 1,423 sq ft

    Lot size: 7,985 sqft

    Year built: 1959

    Walk Score?: 58

  23. 3 beds, 2 full baths

    Home size: 1,568 sq ft

    Year built: 1980

    Parking spots: 1

    Walk Score?: 35

  24. 5 beds, 4 full, 1 part baths

    Home size: 3,713 sq ft

    Lot size: 32,896 sqft

    Year built: 2001

    Parking spots: 4

    Walk Score?: 2

  25. 4 beds, 2 full baths

    Home size: 1,505 sq ft

    Year built: 1980

    Walk Score?: 6

  26. 4 beds, 3 full, 1 part baths

    Home size: 3,204 sq ft

    Year built: 2009

    Walk Score?: 34

  27. 3 beds, 2 full baths

    Home size: 1,108 sq ft

    Year built: 1981

    Walk Score?: 6

  28. 3 beds, 2 full baths

    Home size: 1,350 sq ft

    Lot size: 21,150 sqft

    Year built: 1960

    Parking spots: 4

    Walk Score?: 23

  29. 4 beds, 2 full baths

    Home size: 2,035 sq ft

    Year built: 2003

  30. 4 beds, 2 full, 2 part baths

    Home size: 3,100 sq ft

    Lot size: 15,000 sqft

    Year built: 2003

    Walk Score?: 34

  31. 3 beds, 2 full baths

    Home size: 1,509 sq ft

    Lot size: 7,245 sqft

    Year built: 2004

    Walk Score?: 3

  32. 3 beds, 2 full baths

    Home size: 2,144 sq ft

    Year built: 1990

    Walk Score?: 0

  33. 3 beds, 3 full baths

    Home size: 2,420 sq ft

    Year built: 2002

    Parking spots: 4

    Walk Score?: 45

  34. 3 beds, 2 full baths

    Home size: 1,697 sq ft

    Year built: 2009

  35. 4 beds, 4 full baths

    Home size: 2,200 sq ft

    Lot size: 24,948 sqft

    Year built: 2005

    Walk Score?: 15

  36. 3 beds, 2 full baths

    Home size: 1,295 sq ft

    Year built: 1977

    Walk Score?: 22

  37. 2 beds, 1 full, 1 part baths

    Home size: 900 sq ft

    Year built: 1983

    Walk Score?: 92

  38. 2 beds, 2 full baths

    Home size: 1,202 sq ft

    Year built: 2007

    Walk Score?: 42

  39. 2 beds, 2 full baths

    Home size: 1,202 sq ft

    Year built: 2007

    Walk Score?: 42

  40. 3 beds, 2 full baths

    Home size: 1,463 sq ft

    Year built: 2007

    Walk Score?: 42

  41. 2 beds, 2 full baths

    Home size: 1,202 sq ft

    Year built: 2007

    Walk Score?: 42

  42. 3 beds, 2 full baths

    Home size: 1,463 sq ft

    Year built: 2007

    Walk Score?: 42

  43. 2 beds, 2 full baths

    Home size: 1,202 sq ft

    Year built: 2007

    Walk Score?: 42

  44. 2 beds, 2 full baths

    Home size: 1,202 sq ft

    Year built: 2007

    Walk Score?: 42

  45. 3 beds, 2 full baths

    Home size: 1,463 sq ft

    Year built: 2007

    Walk Score?: 42

  46. 3 beds, 2 full baths

    Home size: 1,463 sq ft

    Year built: 2007

    Walk Score?: 42

  47. 3 beds, 2 full baths

    Home size: 1,463 sq ft

    Year built: 2007

    Walk Score?: 42

  48. 2 beds, 2 full baths

    Home size: 1,202 sq ft

    Year built: 2007

    Walk Score?: 42

  49. 4 beds, 2 full baths

    Home size: 2,500 sq ft

    Lot size: 6,893 sqft

    Year built: 1961

    Walk Score?: 32

  50. 4 beds, 4 full baths

    Home size: 2,231 sq ft

    Year built: 2001

    Walk Score?: 31

Listing information deemed reliable but not guaranteed. Read full disclaimer.

Source: http://sellingsouthal.com/todays-top-foreclosures/

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England to mandate dog microchips by 2016

UK to mandate dog microchips by 2016

Thinking about injecting an identification chip in your pooch? If you live in the southern part of the UK, you won't have a choice. Come 2016, English authorities will require all of the country's pups to have embedded microchips, so they can be returned to their owners if ever they run astray. The United Kingdom's Environment Department says some 60 percent of the country's 8 million dogs already have the tags, but beginning in three years, owners who don't spring for the device could be forced to pay fines of up to £500 (about $780). Cat microchipping will remain optional, since felines are less likely to wander outdoors. And "World's Cutest Dog" fans need not worry about their precious Boo getting the forced implant -- the famed Pomeranian (pictured above) is based in San Francisco, some 5,000 miles from the Queen's needle.

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Source: AP (Huffington Post)

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/MkHGkauZHfQ/

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